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Tomi P Mäkelä Selected Research

Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal)

1/2018Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.
10/2013N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice.
9/2011LKB1 signaling in advancing cell differentiation.
11/2008Lkb1 is required for TGFbeta-mediated myofibroblast differentiation.
10/2004Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

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Tomi P Mäkelä Research Topics

Disease

15Neoplasms (Cancer)
01/2022 - 01/2003
5Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal)
01/2018 - 10/2004
5Polyps
10/2013 - 10/2004
3Carcinogenesis
01/2018 - 11/2004
2Breast Neoplasms (Breast Cancer)
01/2018 - 11/2015
1Adenocarcinoma of Lung
01/2022
1Colonic Neoplasms (Colon Cancer)
01/2018
1Glioblastoma (Glioblastoma Multiforme)
08/2013
1Adenoma (Adenomas)
09/2012
1Inflammation (Inflammations)
09/2012
1Stomach Neoplasms (Stomach Cancer)
09/2012
1Primary Effusion Lymphoma
11/2004
1Gastric Polyposis
10/2004

Drug/Important Bio-Agent (IBA)

13Phosphotransferases (Kinase)IBA
01/2020 - 01/2003
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2013 - 10/2004
2Celecoxib (Celebrex)FDA Link
09/2012 - 10/2004
1Interleukin-11 (Interleukin 11)IBA
01/2018
1Biomarkers (Surrogate Marker)IBA
01/2018
1Cadherins (E-Cadherin)IBA
01/2018
14- hydroxy- 3- (4- (2- hydroxyphenyl)phenyl)- 6- oxo- 7H- thieno(2,3- b)pyridine- 5- carbonitrileIBA
11/2015
1Proteins (Proteins, Gene)FDA Link
09/2012
1Pharmaceutical PreparationsIBA
09/2012
1Trefoil Factor-1IBA
09/2012
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
09/2012
1Messenger RNA (mRNA)IBA
09/2012
1AntralIBA
05/2010
1Pepsinogen CIBA
05/2010
1Actins (F Actin)IBA
05/2010
1Transforming Growth Factor beta (TGF-beta)IBA
04/2008
1CyclinsIBA
11/2004
1AMP-Activated Protein KinasesIBA
01/2003

Therapy/Procedure

1Immunotherapy
01/2022
1Chemoprevention
10/2004